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METHOD OF PREDICTING IMMUNE-RELATED ADVERSE EVENT IN USE OF IMMUNE CHECKPOINT INHIBITOR

机译:预测免疫检查点抑制剂使用中与免疫有关的不良事件的方法

摘要

The present invention provides a novel method of obtaining data for predicting the onset of an adverse event due to administration of at least one antibody drug selected from an anti-PD-1 antibody, an anti-PD-L1 antibody, an anti-CTLA4 antibody, and an antigen-binding fragment thereof, or a novel method of predicting the onset of the adverse event. More specifically, the present invention provides a method of obtaining data for predicting the onset of an adverse event or a method of predicting the onset of the adverse event, comprising measuring a level of at least one marker selected from sCD163 and CXCL5 in a biological sample collected from a subject administered the antibody drug.
机译:本发明提供了一种新的获得数据的方法,该数据用于预测由于施用至少一种选自抗PD-1抗体,抗PD-L1抗体,抗CTLA4抗体的抗体药物而引起的不良事件的发生,其抗原结合片段或预测不良事件发作的新方法。更具体地,本发明提供一种获得用于预测不良事件的发作的数据的方法或一种预测不良事件的发作的方法,包括测量生物样品中选自sCD163和CXCL5的至少一种标记物的水平。从施用抗体药物的受试者收集。

著录项

  • 公开/公告号US20190202915A1

    专利类型

  • 公开/公告日2019-07-04

    原文格式PDF

  • 申请/专利权人 TOHOKU UNIVERSITY;

    申请/专利号US201716314474

  • 发明设计人 TAKU FUJIMURA;

    申请日2017-06-30

  • 分类号C07K16/28;C07K14/52;C07K16/24;C07K14/705;A61P35;G01N33/68;G01N33/15;

  • 国家 US

  • 入库时间 2022-08-21 12:12:42

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