embedded image or a pharmaceutically acceptable salt thereof, wherein R1 and R2 are as defined herein."/> Substituted pyrimidines for treatment of chronic cough, neuronal hypersensitivity underlying chronic cough, neuronal hypersensitivity underlying sub-acute cough and neuronal hypersensitivity underlying acute cough
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Substituted pyrimidines for treatment of chronic cough, neuronal hypersensitivity underlying chronic cough, neuronal hypersensitivity underlying sub-acute cough and neuronal hypersensitivity underlying acute cough

机译:取代的嘧啶类药物,用于治疗慢性咳嗽,慢性咳嗽的神经元超敏反应,亚急性咳嗽的神经元超敏反应和急性咳嗽的神经元超敏反应

摘要

Methods for treating cough, chronic cough and urges to cough associated with respiratory diseases with a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of Formula (I):; embedded image or a pharmaceutically acceptable salt thereof, wherein R1 and R2 are as defined herein.
机译:用P2X3和/或P2X2 / 3受体拮抗剂治疗与呼吸系统疾病相关的咳嗽,慢性咳嗽和急咳的方法,该方法包括向有需要的受试者施用有效量的式(I)的化合物: ; “嵌入式图像” 或其药学上可接受的盐,其中R 1 和R 2 如本文所定义。

著录项

  • 公开/公告号US10206922B2

    专利类型

  • 公开/公告日2019-02-19

    原文格式PDF

  • 申请/专利权人 AFFERENT PHARMACEUTICALS. INC.;

    申请/专利号US201715665595

  • 发明设计人 ANTHONY P. FORD;BRUCE G. MCCARTHY;

    申请日2017-08-01

  • 分类号A61K31/505;C07D239/48;A61K9;A61K9/20;A61K9/10;A61K9/107;A61K9/48;A61K47/26;

  • 国家 US

  • 入库时间 2022-08-21 12:13:01

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