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Nonlinear optical photodynamic therapy (NLO-PDT) of the cornea

机译:角膜的非线性光学光动力疗法(NLO-PDT)

摘要

The embodiments include method of nonlinear optical photodynamic therapy of tissue including the steps of providing pulsed infrared laser light for two-photon excited fluorescence tissue exposure, and selectively focusing the pulsed infrared laser light within the tissue at a focal plane to activate a photosensitizing agent to generate free radicals within a highly resolved axial and lateral spatial domain in the tissue. The invention is also directed to an apparatus for performing nonlinear optical photodynamic therapy of tissue including a pulsed infrared laser for providing two-photon excited fluorescence beam tissue exposure, a scanner for selectively and controllably moving the tissue and the beam relative to each other, and optics for selectively focusing the pulsed infrared laser light within the tissue at a point in a focal plane to activate a photosensitizing agent to generate free radicals within a highly resolved axial and lateral spatial domain in the tissue.
机译:实施例包括对组织进行非线性光学光动力疗法的方法,该方法包括以下步骤:提供脉冲红外激光以用于双光子激发的荧光组织曝光;以及选择性地将脉冲红外激光聚焦在组织内的焦平面上以激活光敏剂以将光敏剂活化。在组织中高度分解的轴向和横向空间域内产生自由基。本发明还涉及一种用于执行组织的非线性光学光动力疗法的设备,包括用于提供双光子激发的荧光束组织曝光的脉冲红外激光,用于选择性地和可控制地使组织和束相对于彼此移动的扫描仪,以及用于选择性地将脉冲红外激光聚焦在组织内焦平面上某一点的光学器件,以激活光敏剂以在组织中高度分辨的轴向和横向空间域内产生自由基。

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