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Tumor deconstruction platform for the analysis of intra-tumor heterogeneity
Tumor deconstruction platform for the analysis of intra-tumor heterogeneity
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机译：用于肿瘤内异质性分析的肿瘤解构平台
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摘要
The present invention provides a method for concurrent resolution of the cancer stem cell (CSC) derived hierarchy, genetic instability, differentially cycling cells and host cells recruited for performing tumor growth supporting functions; and (ii) quantification, monitoring and analysis of these populations. The first level of analysis can be carried out using either CSC- and progenitor-specific markers or a marker-free approach based on label-chase to resolve the tumor regenerative hierarchy. The next level involves combinatorial quantification of differential DNA-RNA contents to identify recruited host and tumor cell variants resulted from genetic instability and differential cycling within the tumor.
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