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Novel compound showing antagonism against islet amyloid polypeptide (IAPP) -induced β-cell damage and impaired glucose tolerance

机译:显示出对胰岛淀粉样多肽(IAPP)诱导的β细胞损伤和葡萄糖耐量降低的拮抗作用的新型化合物

摘要

Described are molecules specifically binding to human islet amyloid polypeptide (hIAPP) also known as amylin, particularly human-derived antibodies as well as fragments, derivatives and variants thereof for antagonizing islet amyloid polypeptide (IAPP) induced β-cell damage and impaired glucose tolerance winch are symptoms typically associated with diabetes mellitus type 2 (T2D).
机译:描述了与人胰岛淀粉样多肽(hIAPP)(也称为胰岛淀粉样多肽)特异性结合的分子,尤其是人源抗体及其片段,衍生物和变体,用于拮抗胰岛淀粉样多肽(IAPP)诱导的β细胞损伤和糖耐量受损的绞盘是通常与2型糖尿病(T2D)相关的症状。

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