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Drug-carrying titanium screw, drug-carrying titanium screw and preparation method thereof

机译:载药钛螺丝,载药钛螺丝及其制备方法

摘要

PROBLEM TO BE SOLVED: To provide a drug-carrying titanium screw, a drug-carrying titanium screw, and a preparation method thereof. The present invention discloses a method for preparing a drug-carrying titanium screw, wherein the drug-carrying titanium screw has a titanium screw body and a drug-carryable drug provided on the surface of the titanium screw body. And a pore ceramic layer. The method includes a pretreatment step of a titanium screw body surface, a preparation step of a hyaluronic acid-alginate microsphere that is a pore type, a preparation step of a titanium sol solution, a coating and pore forming step, and a firing step. . The present invention further discloses a drug-carrying titanium screw obtained by the above preparation method, a drug-carrying titanium screw prepared by the drug-carrying titanium screw, and a preparation method thereof. In the present invention, a porous ceramic layer is produced on the surface of a titanium screw body of a snout joint, and the ceramic has corrosion resistance and wear resistance. Therefore, metal ions on the titanium screw surface are difficult to enter the human body. At the same time, no fallout and wear powders are generated, avoiding `` inflammation due to wear powder '' and foreign body reaction to the human body, and being able to fill various drugs such as bacteriostatic drugs and fusion promoters and target localization. In addition, the drug is released slowly and has a good medical use. [Selection figure] None
机译:解决的问题:提供载药的钛螺钉,载药的钛螺钉及其制备方法。本发明公开了一种载药钛螺丝的制备方法,其中所述载药钛螺丝具有钛螺丝体和设置在所述钛螺丝体表面上的载药药。并有孔陶瓷层。该方法包括钛螺杆体表面的预处理步骤,孔型透明质酸-海藻酸盐微球的制备步骤,钛溶胶溶液的制备步骤,涂层和孔形成步骤以及烧制步骤。 。本发明还公开了一种通过上述制备方法得到的载药钛螺钉,通过载药钛螺钉制备的载药钛螺钉及其制备方法。在本发明中,在管嘴接头的钛螺丝体的表面上形成多孔陶瓷层,并且该陶瓷具有耐腐蚀性和耐磨损性。因此,钛螺钉表面的金属离子难以进入人体。同时,不会产生沉淀和磨损粉,避免了``由于磨损粉引起的炎症''和异物对人体的反应,并且能够填充各种药物,例如抑菌药和融合促进剂以及靶向定位。另外,该药物释放缓慢并且具有良好的医学用途。 [选择图]无

著录项

  • 公开/公告号JP2019502410A

    专利类型

  • 公开/公告日2019-01-31

    原文格式PDF

  • 申请/专利号JP20170544353

  • 发明设计人 劉青;蒲▲叢▼;

    申请日2016-12-09

  • 分类号A61L27/06;A61L27/30;A61L27/34;A61L27/40;A61L27/54;A61L27/56;A61B17/04;A61B17/11;

  • 国家 JP

  • 入库时间 2022-08-21 12:19:32

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