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LAGLIDADG homing endonuclease that cleaves CC chemokine receptor type 5 (CCR5) gene and its use
LAGLIDADG homing endonuclease that cleaves CC chemokine receptor type 5 (CCR5) gene and its use
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机译：切割CC趋化因子受体5型（CCR5）基因的LAGLIDADG归巢内切核酸酶及其用途
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摘要
Disclosed herein are compositions for inactivating the human CCR5 gene comprising engineered LAGLIDADG homing endonucleases (LHEs) and their derivatives, particularly derived from members of the -Onul subfamily of LHE. Polynucleotides encoding such endonucleases, vectors comprising said polynucleotides, cells comprising or having been treated with such endonucleases, and therapeutic compositions deriving therefrom are also provided.
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