首页> 外国专利> Isolation and culture technology of large intestine epithelial stem cells and large intestine epithelial transplantation technology using the same

Isolation and culture technology of large intestine epithelial stem cells and large intestine epithelial transplantation technology using the same

机译:大肠上皮干细胞的分离培养技术及使用该技术的大肠上皮移植技术

摘要

It is an object of the present invention to provide a culture medium for in vitro culture of a colorectal epithelial stem cell or the like, a method of in vitro culturing a colorectal epithelial stem cell or the like using the culture medium, a prophylactic or therapeutic agent for a bowel disease containing a colorectal epithelial stem cell or the like cultured by the method, a method of administrating, i.e., transplanting a colorectal epithelial stem cell or the like cultured by the method to a bowel disease patient, and a method of isolating a colorectal epithelial stem cell or the like. The culture medium for in vitro culture of a colorectal epithelial stem cell and/or a colorectal epithelial cell characteristically contains serum albumin, Wnt3a, and r-spondin-1.
机译:本发明的目的是提供一种用于结肠直肠上皮干细胞等的体外培养的培养基,使用该培养基体外培养结肠直肠上皮干细胞等的方法,预防性或治疗性包含通过该方法培养的结肠直肠上皮干细胞等的肠疾病用药剂,将通过该方法培养的结肠直肠上皮干细胞等给予肠疾病患者的方法,即移植方法。结肠直肠上皮干细胞等。用于大肠上皮干细胞和/或大肠上皮细胞的体外培养的培养基特征性地包含血清白蛋白,Wnt3a和r-spondin-1。

著录项

  • 公开/公告号JP6544726B2

    专利类型

  • 公开/公告日2019-07-17

    原文格式PDF

  • 申请/专利权人 国立大学法人 東京医科歯科大学;

    申请/专利号JP20170208883

  • 发明设计人 渡辺 守;中村 哲也;

    申请日2017-10-30

  • 分类号C12N5/071;A61P1;A61K35/38;A61P1/04;A61L27/38;C12N15/09;

  • 国家 JP

  • 入库时间 2022-08-21 12:21:32

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