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DETECTION OF BORRELIA BURGDORFERI SENSU LATO IN PATIENTS WITH LATE DISSEMINATED LYME INFECTION

机译：弥漫性莱姆病感染患者的伯氏疏螺旋体检测

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摘要

The presence invention relates to an ex vivo method of detecting a Borrelia burgdorferi sensu lato active infection in a skin sample of a subject, said skin sample being treated with an immunosuppressive dermocorticoid before sampling, comprising the step of detecting, in said skin sample, at least one protein of Borrelia burgdorferi sensu lato chosen in the group comprising VIsE, flagellin, GAPDH, flagellar filament outer layer protein, L-lactate dehydrogenase, enolase, oligopeptide ABC transporter periplasmic oligopeptide-binding protein, neutrophil activating protein, 2,3-biphosphoglycerate-dependent phosphoglycerate mutase, elongation factor Tu, GroEL, Lipoprotein gi|256055301 or gi|365823350 or any Borrelia species homolog thereof, Hypothetical protein BbuN40_0563 or any Borrelia species homolog thereof, and DbpA.The invention also relates to a set of polypeptides of Borrelia burgdorferi sensu lato and to the use of the set of polyeptides in an ex vivo method of detecting Borrelia burgdorferi sensu lato in a subject likely to present an active Lyme infection.

机译：本发明涉及在受试者皮肤样品中检测 Borrelia burgdorferi sento lato活动性感染的离体方法，所述皮肤样品在进行免疫抑制前使用皮质类固醇激素治疗。采样，包括在所述皮肤样品中检测至少一种选自以下的蛋白质：Borrelia burgdorferi sensu lato，所述蛋白质选自VIsE，鞭毛蛋白，GAPDH，鞭毛丝外层蛋白，L-乳酸脱氢酶，烯醇化酶，寡肽ABC转运蛋白周质寡肽结合蛋白，嗜中性粒细胞活化蛋白，2,3-二磷酸甘油酸依赖性磷酸甘油酸变位酶，延伸因子Tu，GroEL，脂蛋白gi | 256055301或gi | 365823350或任何 Borrelia 物种同源蛋白，假设蛋白BbuN40_0563或任何 Borrelia 物种同源蛋白和DbpA。本发明还涉及一套 Borrelia burgdorferi sensu lato的多肽，以及该组多肽在离体方法中检测 Borrelia burgdorferi <可能表现出活跃的莱姆感染的受试者中的sensu lato。 展开▼

著录项

公开/公告号EP3410117A1

专利类型

公开/公告日2018-12-05

原文格式PDF

申请/专利权人 UNIVERSITÉ DE STRASBOURG;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE;
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申请/专利号EP20170305648

发明设计人 BOULANGER NATHALIE;SABATIER LAURENCE;WESTERMANN BENOÎT;
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申请日2017-06-02

分类号G01N33/569;

国家 EP

入库时间 2022-08-21 12:25:42

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