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PHOTO-SWITCHABLE CHEMICAL INDUCERS OF DIMERIZATION FOR CONTROL OF PROTEIN FUNCTION IN CELLS BY LIGHT
PHOTO-SWITCHABLE CHEMICAL INDUCERS OF DIMERIZATION FOR CONTROL OF PROTEIN FUNCTION IN CELLS BY LIGHT
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机译:光开关化学转化的化学诱导剂,通过光控制细胞中的蛋白质功能
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摘要
The present application refers to photo-switchable chemical inducers of dimerization for control of protein interactions in cells by light. A compound, a test system, methods and uses are disclosed how the invention can be applied in the investigation of intracellular protein interactions. The system is composed of a compound of the general formula (I) as the photo-caged dimerizer, with the ability to covalently bind to HaloTag and a high affinity binding to eDHFR, respectively. The system can be activated and deactivated selectively on illumination with light under different irradiation conditions.
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