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COMPOSITION FOR DIFFERENTIATION OF DENTAL PULP STEM CELLS INTO ODONTOBLAST PROGENITOR CELLS AND IGG OR IGM TYPE MONOCLONAL ANTIBODY SPECIFICALLY BINDING TO SURFACE OF ODONTOBLAST PROGENITOR CELLS
COMPOSITION FOR DIFFERENTIATION OF DENTAL PULP STEM CELLS INTO ODONTOBLAST PROGENITOR CELLS AND IGG OR IGM TYPE MONOCLONAL ANTIBODY SPECIFICALLY BINDING TO SURFACE OF ODONTOBLAST PROGENITOR CELLS
The present invention relates to a composition for the differentiation of dental pulp stem cells into odontoblasts and an IgG or IgM type monoclonal antibody that specifically binds to the surface of odontoblasts differentiated from the stem cells. According to the present invention, BMP2 and BMP4 are optimally combined to significantly increase the differentiation efficiency of dental pulp stem cells into odontoblasts, to induce the mineralization of the matrix, and to improve the differentiation ability of odontoblasts into dentin. Further, the IgG or IgM monoclonal antibody that specifically binds to the surface of odontoblasts of the present invention is used to effectively isolate and purify odontoblasts, which can be useful for tissue regeneration and differentiation.
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