首页> 外国专利> METHOD FOR IDENTIFYING CLINICAL TRIAL RESPONDERS FROM A PLACEBO GROUP IN MAJOR DEPRESSION

METHOD FOR IDENTIFYING CLINICAL TRIAL RESPONDERS FROM A PLACEBO GROUP IN MAJOR DEPRESSION

机译:从主要抑郁症的地方人群中识别临床试验反应者的方法

摘要

The present invention provides methods and kits for identifying clinical trial responders from a placebo group in clinical trials for treating depression and/or major depressive disorder (MDD). The present invention further provides methods and kits for treating depression and/or MDD in an individual, and for identifying the likelihood that an individual suffering from depression and/or MDD will respond favorably to administration of a placebo and/or experience an enhanced placebo effect when administered a placebo. These methods and kits comprise determining the presence of polymorphisms in the Brain-Derived Neurotrophic Factor gene (BDNF), the B-Cell CLL/Lymphoma 2 gene (BCL2), and/or intergenic regions in an individual.
机译:本发明提供了在治疗抑郁症和/或重度抑郁症(MDD)的临床试验中从安慰剂组中鉴定临床试验应答者的方法和试剂盒。本发明进一步提供了用于治疗个体中的抑郁症和/或MDD,并鉴定患有抑郁症和/或MDD的个体对安慰剂的给药有利地应答和/或经历增强的安慰剂作用的可能性的方法和试剂盒。服用安慰剂时。这些方法和试剂盒包括确定个体中脑源性神经营养因子基因(BDNF),B细胞CLL /淋巴瘤2基因(BCL2)和/或基因间区域中多态性的存在。

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