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PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING DEMENTIA AND COGNITIVE DYSFUNCTION, CONTAINING DONEPEZIL OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF AND MEMANTINE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, AND PREPARATION METHOD THEREFOR
PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING DEMENTIA AND COGNITIVE DYSFUNCTION, CONTAINING DONEPEZIL OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF AND MEMANTINE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, AND PREPARATION METHOD THEREFOR
An immediate-release type pharmaceutical composition for preventing or treating dementia and cognitive dysfunction, including donepezil or a pharmaceutically acceptable salt thereof and memantine or a pharmaceutically acceptable salt thereof, and a method of preparing the pharmaceutical composition are disclosed. The method includes: granulating donepezil or a pharmaceutically acceptable salt thereof by a wet process; and adding memantine or a pharmaceutically acceptable salt thereof to the granulated donepezil or a pharmaceutically acceptable salt thereof and directly compressing and homogenizing the resulting mixture, thereby addressing problems such as reduced efficacy due to a decrease in elution of a donepezil active ingredient upon co-administration of Aricept® (donepezil hydrochloride) and Ebixa® (memantine hydrochloride), which are commercially available, and content uniformity is secured by selecting an excipient having a particle size similar to that of particles of the active ingredients. In addition, the pharmaceutical composition of the present invention is very stable without related substances.
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