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ATROPINE SULFATE RAPIDLY-DISINTEGRATING SUBLINGUAL TABLETS, METHODS FOR MANUFACTURE, AND METHODS FOR USE THEREOF FOR TREATMENT OF ACUTE ORGANOPHOSPHATE TOXICITY
ATROPINE SULFATE RAPIDLY-DISINTEGRATING SUBLINGUAL TABLETS, METHODS FOR MANUFACTURE, AND METHODS FOR USE THEREOF FOR TREATMENT OF ACUTE ORGANOPHOSPHATE TOXICITY
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机译：阿托品硫酸盐可快速降解的舌下片剂，制造方法及其用于治疗急性有机磷酸酯毒性的方法
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摘要
The invention provides atropine sulfate (AS) rapidly-disintegrating sublingual tablets (RDSTs) in a sublingual dosage form and methods for therapeutic use of the AS RDSTs for treatment of organophosphate (OP) exposure and acute toxicity. The AS RDSTs provide an alternative easy-to-use dosage form for the management of organophosphate toxicity. Additionally, the invention provides methods for formulation and quality evaluation of the atropine sulfate rapidly-disintegrating sublingual tablets.
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机译：本发明提供了舌下剂型的硫酸阿托品（AS）快速崩解舌下片剂（RDST）以及用于治疗AS RDST的有机用途（OP）暴露和急性毒性的治疗方法。 AS RDST为管理有机磷酸酯毒性提供了一种易于使用的替代剂型。另外，本发明提供了用于配制和评估阿托品硫酸盐快速崩解舌下片剂的方法。
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