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首页> 外国专利> Selective release system for tumor therapeutics and tumor diagnostics and biosensor for tumor tissue

Selective release system for tumor therapeutics and tumor diagnostics and biosensor for tumor tissue

机译：用于肿瘤治疗和肿瘤诊断的选择性释放系统以及用于肿瘤组织的生物传感器

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The present invention relates generally to a tumor tissue sensor and a local delivery system of targeted tumor therapy and tumor diagnostics therapeutics / diagnostics. Concretely, the invention relates to a cation stabilized biopolymer gel, especially an alginate gel, for use as a carrier matrix for a tumor therapeutic and / or or tumor diagnosis, characterized in that the gel in the presence of a stimulus formed by tumor cells or tumor tissue, in particular lysyl oxidase (LOX) destabilized and the tumor therapeutic and / or tumor diagnosis can be released, and a pharmaceutical composition containing this cation-stabilized biopolymer gel A related aspect of the invention relates to an in vitro method of detecting the presence and / or amount of a tumor-specific product in the body of a P characterized in that a physiological sample of a patient to whom a pharmaceutical composition according to the invention has been administered is based on the presence and / or amount of a reporter substance released after the destabilization of the gel as a result of contact with the tumor-specific product to be detected, and, if appropriate, compared with reference values.
机译：本发明总体上涉及靶向肿瘤治疗和肿瘤诊断疗法/诊断的肿瘤组织传感器和局部递送系统。具体地，本发明涉及阳离子稳定的生物聚合物凝胶，尤其是藻酸盐凝胶，其用作用于肿瘤治疗和/或肿瘤诊断的载体基质，其特征在于该凝胶在存在由肿瘤细胞或肿瘤细胞形成的刺激的情况下。可以释放不稳定的肿瘤组织，尤其是赖氨酰氧化酶（LOX），并可以释放肿瘤治疗和/或肿瘤诊断，并且包含该阳离子稳定的生物聚合物凝胶的药物组合物。 P体内肿瘤特异性产物的存在和/或量，其特征在于已向其施用根据本发明的药物组合物的患者的生理样品基于报告物的存在和/或量由于与待检测的肿瘤特异性产物接触而在凝胶失稳后释放的物质，并在适当情况下与参照物比较e值。

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