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首页> 外国专利> METHOD OF INCREASING EFFECTIVENESS OF AUXILIARY REPRODUCTIVE TECHNOLOGIES IN PATIENTS WITH REPEATED NON-EFFECTIVE ATTEMPTS OF IMPLANTATION

METHOD OF INCREASING EFFECTIVENESS OF AUXILIARY REPRODUCTIVE TECHNOLOGIES IN PATIENTS WITH REPEATED NON-EFFECTIVE ATTEMPTS OF IMPLANTATION

机译：重复无效植入尝试的患者提高辅助生殖技术功效的方法

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FIELD: medicine.;SUBSTANCE: invention relates to medicine, namely, gynecology and pathological anatomy. Autologous platelet-enriched blood plasma is used, while the preparation of the endometrium of the patient is performed using a standardized protocol of hormone replacement therapy against the background of monitoring the growth of the endometrium, from 3/4 days of the cycle prescribe estradiolavalerate 2 mg 2 times a day and transdermal form of estradiol in the starting dose of 1.25 g 2 times a day. As a support for the luteal phase, micronized progesterone is used vaginally at a daily dose of 90 mg and progesterone oil solution 1 % – 1 ml intramuscularly once a day. Moreover, the transfer of viable embryos is performed on the 6th day of administration of progesterone, and on the 10/11 day of the cycle, after ultrasonic evaluation of the thickness of the endometrium, intrauterine perfusion of 1.0–1.5 ml of an autologous blood plasma enriched with platelets is carried out using an insemination catheter.;EFFECT: method increases the expression of growth factors in the endometrium, that leads to an increase in the thickness of the endometrium and an increased likelihood of a successful outcome of assisted reproductive technology.;1 cl, 1 tbl, 2 dwg
机译：技术领域本发明涉及医学，即妇科和病理解剖学。使用自体血小板富集的血浆，而患者的子宫内膜的制备则使用激素替代疗法的标准方案，在监测子宫内膜生长的背景下进行，从周期的3/4天开始规定雌二醇戊酸酯2每天2次，每次口服雌二醇的透皮形式，起始剂量为1.25克，每天2次。作为黄体期的支持物，每天以90 mg的剂量经阴道阴道使用微粉化的孕酮，每天一次肌内注射1％– 1 ml的孕酮油溶液。此外，在给予子宫内膜厚度的超声评估，子宫内腔灌注后，在孕酮给药的第6天和周期的10/11天进行活胚的转移。使用授精导管进行1.0–1.5 ml富含血小板的自体血浆。;效果：该方法可增加子宫内膜中生长因子的表达，从而导致子宫内膜厚度增加和发生子宫内膜异位症的可能性增加。辅助生殖技术的成功成果。; 1 cl，1 tbl，2 dwg

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