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首页> 外国专利> CONJUGATE, MEDICATION AND METHODS OF TREATMENT AND/OR PREVENTION OF DEPRESSION AND DISEASE ASSOCIATED WITH LEWY BODIES CONCRETION

CONJUGATE, MEDICATION AND METHODS OF TREATMENT AND/OR PREVENTION OF DEPRESSION AND DISEASE ASSOCIATED WITH LEWY BODIES CONCRETION

机译：结合体病性结石的治疗和/或预防和预防抑郁症的方法，药物和方法

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FIELD: medicine.;SUBSTANCE: group of inventions relates to medicine and refers to a conjugate comprising at least one selectivity agent specifically binding to at least one neurotransmitter transporter and selected from the group consisting of a selective serotonin reuptake inhibitor (SSRI), a noradrenaline reuptake inhibitor (NRI), a norepinephrine and dopamine reuptake inhibitor (NDRI), and a serotonin, norepinephrine and dopamine reuptake inhibitor (SNDRI), and at least one nucleic acid adapted to specifically bind to a target molecule expressed in a cell in which the neurotransmitter transporter is expressed. Group of inventions also relates to the use of said conjugate in the treatment and / or prevention of a disorder associated with depression, in the treatment and / or prevention of a disease associated with the deposition of Lewy bodies.;EFFECT: group of inventions ensures the start of internalisation of the nucleic acids of the claimed conjugates in cells expressing the neurotransmitter transporters with which they interact.;18 cl, 42 dwg, 2 tbl, 13 ex
机译：发明领域本发明涉及药物，是指包含至少一种与至少一种神经递质转运蛋白特异性结合的选择剂的缀合物，所述选择剂选自选择性5-羟色胺再摄取抑制剂（SSRI），去甲肾上腺素再摄取抑制剂（NRI），去甲肾上腺素和多巴胺再摄取抑制剂（NDRI）和5-羟色胺，去甲肾上腺素和多巴胺再摄取抑制剂（SNDRI），以及至少一种适于与细胞中表达的靶分子特异性结合的核酸表达神经递质转运蛋白。一组发明还涉及所述缀合物在治疗和/或预防与抑郁症有关的病症，在治疗和/或预防与路易氏体沉积有关的疾病中的用途。效果：一组发明确保了在表达与之相互作用的神经递质转运蛋白的细胞中要求保护的缀合物的核酸内化的开始; 18 cl，42 dwg，2 tbl，13 ex

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