首页> 外国专利> METHOD OF DETECTING DISORDERS OF PHYSIOLOGICAL IMMUNOSUPPRESSION IN CHILDREN IN FIRST GENERATION THROUGH PARENTAL LINEAGE WITH HEREDITARY TAINTED IN CONDITIONS OF ALUMINUM EXCESSIVE EXPOSURE

METHOD OF DETECTING DISORDERS OF PHYSIOLOGICAL IMMUNOSUPPRESSION IN CHILDREN IN FIRST GENERATION THROUGH PARENTAL LINEAGE WITH HEREDITARY TAINTED IN CONDITIONS OF ALUMINUM EXCESSIVE EXPOSURE

机译：铝过量暴露条件下通过母系谱系遗传检测儿童第一代生理性免疫抑制异常的方法

页面导航

摘要
著录项
相似文献

摘要

FIELD: medicine.;SUBSTANCE: invention relates to the field of medicine, in particular to molecular genetic diagnosis, and discloses a method for detecting disorder of physiological immunosuppression in children in the first generation through parental lineage with hereditary tainted in conditions of aluminum excessive exposure. Method is characterized in that a combination of the following diagnostic criteria is used: the genetic criterion of the FOXp3 gene, level of T-regulatory lymphocytes CD127 and the level of contamination with aluminum above the reference one. At simultaneous presence of variant homozygous or heterozygous genotypes of the gene FOXp3 T(-3499) C from the son and/or from the mother, decrease in relative and absolute level of T-regulatory lymphocytes in child blood, on the membrane of lymphocytes there is no receptor CD127 (CD127^-), with respect to the lower limit of the physiological norm and when the concentration of aluminum in the blood exceeds the reference level, make a conclusion about the presence of disorder of physiological immunosuppression in child in the first generation through parental lineage with hereditary tainted in conditions of aluminum excessive exposure.;EFFECT: invention can be used to identify the negative impact of aluminum coming from the environment.;1 cl, 1 tbl, 2 ex

机译：发明领域本发明涉及医学领域，尤其涉及分子遗传学诊断，并且公开了一种通过父母血统和铝过量暴露条件下遗传性污染来检测第一代儿童生理免疫抑制异常的方法。。该方法的特征在于使用以下诊断标准的组合：FOXp3基因的遗传标准，T调节淋巴细胞CD127的水平和铝污染水平高于参考水平。在同时存在来自儿子和/或母亲的基因FOXp3 T（-3499）C的纯合或杂合基因变异体时，儿童血液中淋巴细胞膜上T调节淋巴细胞的相对和绝对水平降低不能作为受体CD127（CD127 ^{-），就生理标准的下限而言，当血液中铝的浓度超过参考水平时，得出有关生理障碍的存在的结论第一代通过父母亲谱系对儿童的免疫抑制，并在铝过量暴露的情况下受到遗传性污染。;效果：本发明可用于识别来自环境的铝的负面影响。1cl，1 tbl，2 ex}

著录项

公开/公告号RU2655658C1

专利类型
公开/公告日2018-05-29

原文格式PDF
申请/专利权人 FEDERALNOE BYUDZHETNOE UCHREZHDENIE NAUKI FEDERALNYJ NAUCHNYJ TSENTR MEDIKO-PROFILAKTICHESKIKH TEKHNOLOGIJ UPRAVLENIYA RISKAMI ZDOROVYU NASELENIYA FEDERALNOJ SLUZHBY PO NADZORU V SFERE ZASHCHITY PRAV POTREBITELEJ I BLAGOPOLUCHIYA CHELOVEKA (FBUN FNTS MEDIKO-PROFILAKTICHESKIKH TEKHNOLOGIJ UPRAVLENIYA RISKAMI ZDOROVYU NASELENIYA);
展开▼

申请/专利号RU20170114714
发明设计人 DOLGIKH OLEG VLADIMIROVICH;ZAJTSEVA NINA VLADIMIROVNA;KRIVTSOV ALEKSANDR VLADIMIROVICH;BUBNOVA OLGA ALEKSEEVNA;DIANOVA DINA GUMYAROVNA;OTAVINA ELENA ALEKSEEVNA;BEZRUCHENKO NADEZHDA VLADIMIROVNA;GUSELNIKOV MAKSIM ANATOLEVICH;PERMINOVA IRINA VLADIMIROVNA;MAZUNINA ALENA ALEKSANDROVNA;NIKONOSHINA NATALYA ALEKSEEVNA;
展开▼

申请日2017-04-26
分类号G01N33/68;
国家 RU
入库时间 2022-08-21 12:35:32

相似文献

专利
外文文献