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METHOD FOR COMBINED TREATMENT OF STAGE III NON-SMALL CELL LUNG CANCER USING THERMOCHEMI-RADIOTHERAPY

机译：热化学放射疗法联合治疗Ⅲ期非小细胞肺癌的方法

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摘要

FIELD: medicine.;SUBSTANCE: invention relates to medicine, namely to oncology, and can be used for the combined treatment of stage III non-small cell lung cancer (NSCLC). Conduct 2 courses of preoperative chemotherapy according to the scheme paclitaxel 175 mg/m² and carboplatin AUC 6 in parallel with the course of remote radiation therapy to a total focal dose of 40 Gy against a background of local hyperthermia 2 times a week. Conduct chemotherapy courses on the 1 st and 22 nd days. Course of remote radiation therapy is carried out for 2.5 weeks from the 8th to the 23rd days in a mode of hypofractionation of 3 Gy × once a day, 5 days a week. Apply a course of local hyperthermia, consisting of 10 sessions: 30 minutes after administration of chemotherapy or 1 hour before irradiation for 45–60 minutes at a temperature of 41 to 42 °C from the 1st to the 31st days. Perform surgical treatment 4 weeks after the end of thermochemi-radiotherapy.;EFFECT: method provides an increase in the efficiency of preoperative thermochemi-radiotherapy, a reduction in the incidence of complications due to selective enhancement of tumor damage and reduction of the radiation load on normal tissues and improvement of the treatment results.;1 cl, 1 dwg, 1 ex

机译：发明领域本发明涉及医学，即肿瘤学，可用于III期非小细胞肺癌（NSCLC）的联合治疗。根据方案紫杉醇175 mg / m ^{2 和卡铂AUC 6进行2疗程的术前化疗，同时进行局部放疗，总剂量为40 Gy，同时进行局部热疗每周2次。在第1天和第22天进行化疗课程。从第8天到第23天，以每周3天，每天3 Gy×的次分割模式进行远程放射治疗，疗程为2.5周。进行局部热疗，包括10个疗程：从化疗开始第1天到第31天，在化疗后30分钟或在41至42°C的温度下照射45至60分钟照射1小时之前。热化学放疗结束后4周进行手术治疗;效果：该方法可提高术前热化学放疗的效率，并由于选择性增强肿瘤损害和减少放射线负荷而降低了并发症的发生率正常组织并改善治疗效果。; 1 cl，1 dwg，1 ex}

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公开/公告号RU2654612C1

专利类型
公开/公告日2018-05-21

原文格式PDF
申请/专利权人 FEDERALNOE GOSUDARSTVENNOE BYUDZHETNOE NAUCHNOE UCHREZHDENIE TOMSKIJ NATSIONALNYJ ISSLEDOVATELSKIJ MEDITSINSKIJ TSENTR ROSSIJSKOJ AKADEMII NAUK (TOMSKIJ NIMTS);
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申请/专利号RU20170121445
发明设计人 ZAVYALOV ALEKSANDR ALEKSANDROVICH;TUZIKOV SERGEJ ALEKSANDROVICH;DOBRODEEV ALEKSEJ YUREVICH;STARTSEVA ZHANNA ALEKSANDROVNA;
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申请日2017-06-19
分类号A61N5/10;A61B18/04;A61B17/24;A61K31/337;A61K31/282;A61P35/00;
国家 RU
入库时间 2022-08-21 12:35:34

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