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首页> 外国专利> METHOD OF DIAGNOSTICS OF PHYSICAL DEVELOPMENT DISORDER IN CHILDREN LIVING IN THE CONDITIONS OF COMPLEX LOW-LEVEL POLLUTION OF HABITATS WITH LEAD, MANGANESE, NICKEL, CHROME AND CADMIUM

METHOD OF DIAGNOSTICS OF PHYSICAL DEVELOPMENT DISORDER IN CHILDREN LIVING IN THE CONDITIONS OF COMPLEX LOW-LEVEL POLLUTION OF HABITATS WITH LEAD, MANGANESE, NICKEL, CHROME AND CADMIUM

机译：低铅，锰，镍，铬和镉的复杂低水平污染儿童的身体发育障碍的诊断方法

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FIELD: medicine.;SUBSTANCE: invention relates to medicine, namely to pediatrics, endocrinology and toxicology, and can be used to diagnose physical development disorders of children living in the conditions of complex low-level pollution of the environment with heavy metals. When a physical development disorder is identified from a child, the presence of lead, manganese, nickel, chromium and cadmium is determined in the blood. If they are present, functional and laboratory indicators are determined. As functional indicators, structure and volume of the thyroid gland are determined by ultrasound inspection. As laboratory indicators, insulin growth factor (IGF-1), cortisol levels, serotonin, free thyroxine (T4 free), thyroid-stimulating hormone (TSH), antibodies to thyroid peroxidase (antibodies to TPO), aspartate aminotransferase (ASAT), glutamate, gamma-aminobutyric acid (γ-aminobutyric acid), glutathione peroxidase are measured. If a child has a change in the volume and structure of the thyroid gland, and also at a cortisol level of 224.4–279.2 nmol/cm3; IGF of 185.2–130 ng/ml; T4 free of 14.0–16.4 pmol/l; γ-aminobutyric acid of 0.113–0.197 mcmol/dm3; glutathione peroxidase of 38.5–49.9 ng/ml; serotonin of 244.5–314.3 ng/ml; TTG of 1.5–2.1 ng/cm3; antibodies to TPO of 2.2–3.2 IU/cm3; ASAT of 35.8–49.4 E/dm3; glutamate of 118.31–129.33 mcmol/dm3, a child's physical development disorder associated with complex low-level pollution of the environment with lead, manganese, nickel, chromium and cadmium is diagnosticated.;EFFECT: method allows to informatively and demonstratively conduct diagnostics of the physical development disorder in children caused by the action of low-level combined load of lead, manganese, nickel, cadmium and chromium by evaluating the complex of the most significant indicators.;3 cl, 7 tbl, 1 ex
机译：技术领域本发明涉及医学，即涉及儿科，内分泌学和毒理学，并且可以用于诊断生活在重金属对环境的低水平复杂污染条件下的儿童​​的身体发育障碍。当从儿童中识别出身体发育障碍时，就可以确定血液中铅，锰，镍，铬和镉的存在。如果存在，则确定功能和实验室指标。作为功​​能指标，通过超声检查确定甲状腺的结构和体积。作为实验室指标，胰岛素生长因子（IGF-1），皮质醇水平，5-羟色胺，游离甲状腺素（不含T4），促甲状腺激素（TSH），抗甲状腺过氧化物酶的抗体（抗TPO的抗体），天冬氨酸转氨酶（ASAT），谷氨酸测定γ-氨基丁酸（γ-氨基丁酸），谷胱甘肽过氧化物酶。如果儿童的甲状腺的体积和结构发生了变化，皮质醇水平也在224.4–279.2 nmol / cm 3 范围内; IGF为185.2–130 ng / ml; T4不含14.0-16.4 pmol / l; γ-氨基丁酸为0.113–0.197 mcmol / dm 3 ;谷胱甘肽过氧化物酶为38.5–49.9 ng / ml;血清素为244.5–314.3 ng / ml; TTG为1.5–2.1 ng / cm 3 ; TPO抗体为2.2–3.2 IU / cm 3 ; ASAT为35.8–49.4 E / dm 3 ;谷氨酸118.31–129.33 mcmol / dm 3 ，一种儿童身体发育障碍，与铅，锰，镍，铬和镉对环境的复杂低水平污染相关。已被诊断出来;效果：方法允许通过评估最重要的指标的复杂性，以信息性和说明性的方式诊断由铅，锰，镍，镉和铬的低水平联合负荷所致的儿童身体发育障碍。3cl，7 tbl， 1前

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