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METHOD OF PRODUCING 3-ACYL SUBSTITUTED 2-ARYL(HETERYL)-1H-INDOLE-5,6-DICARBONITRILES

机译:制备3-酰基取代的2-芳基(杂基)-1H-吲哚-5,6-二腈的方法

摘要

FIELD: chemistry.;SUBSTANCE: invention relates to the method of producing new 3-acyl-substituted 2-aryl(heteryl)-1H-indole-5,6-dicarbonitriles in which R1=COCH3, or COC2H5, or COC3H7; R2=C6H5, or 4-CH3C6H4, or 4-OCH3C6H4, or 2-thienyl; R3=CH3, or C2H5, or C3H7, which can be used as precursors for the synthesis of biologically active substances, drugs, phthalocyanines, hexatrienes. The method of producing a 1,2,3-tizamidine 1H-indole-5,6-dicarbonitriles is in the interaction of 2-substituted 1-hydroxy-1H-indole-5,6-dicarbonitriles with the appropriate anhydrides of aliphatic carboxylic acids in the presence of boronfluoridetrietherate, followed by cooling the resulting reaction mass, dissolving into a tenfold excess of cold water, filtering off the precipitated sludge 1,2,3-tizamidine 1H-indole-5,6-dicarbonitriles, washing with water, recrystallization from acetonitrile and air drying. ; .;EFFECT: increasing the yield.;8 ex
机译:发明领域本发明涉及一种新的3-酰基取代的2-芳基(杂基)-1H-吲哚-5,6-二腈的制备方法,其中R 1 = COCH < Sub> 3 ,或COC 2 H 5,或COC 3 H 7 ; R 2 = C6H5或4-CH 3 C 6 H 4 或4-OCH 3 C 6 H 4 或2-噻吩基; R 3 = CH 3 或C 2 H 5 或C 3 H 7 ,可用作合成生物活性物质,药物,酞菁,己三烯的前体。制备1,2,3-噻唑烷1H-吲哚-5,6-二腈的方法是将2-取代的1-羟基-1H-吲哚-5,6-二腈与适当的脂肪族羧酸酐相互作用在三氟化硼硼化物的存在下,冷却所得反应物料,溶于十倍过量的冷水中,滤出沉淀出的污泥1,2,3-噻唑烷1H-吲哚-5,6-二碳腈,用水洗涤,重结晶从乙腈中风干。 ; 。;效果:提高产量。; 8 ex

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