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DESIGN SYNTHESIS AND APPLICATIONS OF UPCONVERSION NANOPARTICLES USING THE FIRST PRINCIPLES

机译:基于第一原理的上转换纳米粒子的设计合成及应用

摘要

The present invention relates to a method for producing a compound of formula (I), which comprises at least one host selected from LiYF 4 , NaY, NaYF 4 , NaGdF 4 and CaF 3 ; At least one sensitizer selected from Sm 3+ , Nd 3+ , Dy 3+ , Ho 3+ and Yb 3+ doped to the host; And at least one activator selected from Er 3+ , Ho 3+ , Tm 3+ and Eu 3+ doped to the host. The upconverted nanoparticles of the present invention can be designed using first-principles calculations to absorb near-infrared wavelengths with stability. It is also possible to use such up-converted nanoparticles in combination with hyaluronic acid to utilize them in various places in the body having hyaluronic acid receptors, to provide hyaluronic acid-upturned nanoparticles capable of specifically targeting and maintaining body maintenance period and biocompatibility Lt; / RTI
机译:式(I)化合物的制备方法技术领域本发明涉及式(I)化合物的制备方法,其包含选自LiYF 4 ,NaY,NaYF 4 ,NaGdF 4 和CaF 3 ;从Sm 3 + ,Nd 3 + ,Dy 3 中至少选择一种敏化剂> + ,何 3 + 和Yb 3 + 掺杂到主机;并且从Er 3 + ,Ho 3 + ,Tm 3 + 和Eu 3 + 掺杂到主机中。可以使用第一原理计算来设计本发明的上转换纳米颗粒,以稳定地吸收近红外波长。还可以将这种上转换的纳米粒子与透明质酸结合使用,以在具有透明质酸受体的体内各个位置使用它们,以提供透明质酸向上转换的纳米粒子,其能够特异性地靶向并维持身体维持期和生物相容性Lt。 / RTI>

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