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p27Kip1 HETEROCYCLIC COMPOUND AND P27 KIP1 DEGRADATION INHIBITOR

机译：p27Kip1杂环化合物和P27 KIP1降解抑制剂

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摘要

a novel heterocyclic compound or a salt thereof useful for selectively inhibiting the degradation of p27 ^Kip1 . This compound or its salt is represented by the following formula (1). [Wherein A represents an alkyl group, a cycloalkyl group, an aryl group, or a heterocyclic group, the group A may have a substituent; Ring B represents a 5- to 8-atom monocyclic heterocyclic ring or a condensed ring containing the monocyclic heterocyclic ring, ring B may have a substituent; Ring C represents an aromatic ring, ring C may have a substituent; L represents a linker in which the main chain has 3 to 5 atoms selected from a carbon atom, a nitrogen atom, an oxygen atom and a sulfur atom, and also has at least one hetero atom selected from a nitrogen atom, an oxygen atom and a sulfur atom, L may have a substituent; n is 0 or 1;

机译：一种新型的杂环化合物或其盐，可用于选择性抑制p27 ^{Kip1 的降解。该化合物或其盐由下式（1）表示。 [其中A表示烷基，环烷基，芳基或杂环基，基团A可具有取代基;环B表示5至8个原子的单环杂环或含有单环杂环的稠环，环B可具有取代基;环C代表芳环，环C可以具有取代基; L表示其中主链具有选自碳原子，氮原子，氧原子和硫原子的3至5个原子，并且还具有选自氮原子，氧原子和L为硫原子，可以具有取代基。 n为0或1;}

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公开/公告号KR101844615B1

专利类型
公开/公告日2018-05-14

原文格式PDF
申请/专利权人 아스카 세이야쿠 가부시키가이샤;
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申请/专利号KR20137001370
发明设计人 우치다 히로시;아사가라스 아키라;마츠이 데루아키;
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申请日2011-07-01
分类号C07D235/06;A61K31/4184;A61K31/437;C07D231/40;C07D403/12;C07D405/14;C07D409/12;C07D417/12;C07D417/14;C07D471/04;C07D487/04;
国家 KR
入库时间 2022-08-21 12:38:06

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