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Method of surface modification for improving dyeing property of colored micro-particle beads of cellulose acetate for diagnosis reagent

机译:用于改进诊断试剂乙酸纤维素的着色微粒珠的染色性能的表面改性方法

摘要

TECHNICAL FIELD The present invention relates to a surface modification method for enhancing the dyeability of cellulose acetate colored particulate beads for diagnostic reagents, and more particularly, to a method for modifying the surface of cellulose acetate nanoparticles to further improve the dyeability of the cellulose acetate nanobeads obtained by emulsifying solvent evaporation (emulsion method) . According to the surface modification method for improving dyeability of cellulose acetate colored microparticles for diagnostic reagents of the present invention, in the case of cellulose acetate colored microparticle beads prepared by the emulsion method, which is a conventional method, the residual hydroxy groups have excellent water dispersibility and hydrophobic surface properties , It is possible to use the immunochromatographic kit as a polymer probe. However, since the number of hydroxy groups is relatively small and the binding property with a coloring agent such as a dye is not high, the utility as a diagnostic reagent is high However, in the present application, it is possible to enhance the applicability as a diagnostic reagent by improving the dyeability, and further, the problem of adsorption with proteins can be solved by improving the surface area by producing the surface in a corrugated form due to surface modification The.
机译:表面改性方法技术领域本发明涉及用于增强用于诊断试剂的乙酸纤维素彩色颗粒珠的可染性的表面改性方法,更具体地,涉及用于对乙酸纤维素纳米颗粒的表面进行改性以进一步改善乙酸纤维素纳米珠的可染色性的方法。通过乳化溶剂蒸发获得(乳化法)。根据本发明的用于改进用于诊断试剂的乙酸纤维素色的微粒的可染性的表面改性方法,在通过乳液法制备的乙酸纤维素色的微粒珠的情况下,这是常规方法,残留的羟基具有优异的水。分散性和疏水性表面性质,可以将免疫色谱试剂盒用作聚合物探针。但是,由于羟基数较少,与染料等着色剂的结合性不高,因此作为诊断试剂的实用性高。但是,在本申请中,可以提高其适用性。通过改善染色性,可作为一种诊断试剂,此外,通过表面改性而形成波纹状表面,可通过改善表面积来解决蛋白质吸附的问题。

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