首页> 外国专利> Type-1 procollagen Cosmetic composition containing a new peptide effective in stimulating Type-1 procollagen synthesis for wrinkles improvement.

Type-1 procollagen Cosmetic composition containing a new peptide effective in stimulating Type-1 procollagen synthesis for wrinkles improvement.

机译:Type-1前胶原蛋白包含有效刺激Type-1前胶原蛋白合成以改善皱纹的新型肽的化妆品组合物。

摘要

The present invention relates to peptides represented by chemical formulas 1-4, which show the effect of promoting collagen synthesis while not suppressing the cell growth; a cosmetic composition for reducing skin wrinkles, which comprises such peptides as effective components; a topical agent for preventing skin wrinkles; and a pharmaceutical composition for preventing and treating skin diseases. [Chemical formula 1] [Cys-Lys-X-Lys] [Chemical formula 2] [Lys-Val-X-Cys] [Chemical formula 3] [Cys-Lys-X-Lys]_2 [Chemical formula 4] [Lys-Val-X-Cys]_2. In the chemical formulas 1-4, X is selected from glutamic acid, aspartic acid, histidine, phenylalanine, alanine, cysteine, glycine, glutamine, asparagine, arginine, leucine, isoleucine, serine, tyrosine, threonine, lysine, tryptophan, proline, and valine; and [ ]_2 may represent a dimer having transformed a cysteine residue, a thiol group (-SH) to a reduced form (-S-S-).
机译:本发明涉及由化学式1-4表示的肽,其显示出促进胶原蛋白合成而不抑制细胞生长的作用。用于减少皮肤皱纹的化妆品组合物,其包含这样的肽作为有效成分;防止皮肤皱纹的外用剂;以及用于预防和治疗皮肤疾病的药物组合物。 [化学式1] [Cys-Lys-X-Lys] [化学式2] [Lys-Val-X-Cys] [化学式3] [Cys-Lys-X-Lys] _2 [化学式4] [Lys -Val-X-Cys] _2。在化学式1-4中,X选自谷氨酸,天冬氨酸,组氨酸,苯丙氨酸,丙氨酸,半胱氨酸,甘氨酸,谷氨酰胺,天冬酰胺,精氨酸,亮氨酸,异亮氨酸,丝氨酸,酪氨酸,苏氨酸,赖氨酸,色氨酸,脯氨酸,和缬氨酸; [] _2可以表示将半胱氨酸残基,巯基(-SH)转变为还原形式(-S-S-)的二聚体。

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