首页> 外国专利> Marker for predicting lymph node metastasis and method for predicting lymph node metastasis using same

Marker for predicting lymph node metastasis and method for predicting lymph node metastasis using same

机译:预测淋巴结转移的标志物和使用其的预测淋巴结转移的方法

摘要

The present invention relates to a composition for diagnosing a metastatic gastric cancer, and a method to predict lymph node metastasis in an initial stage of gastric cancer using the method. According to the present invention, the composition comprises a probe, a primer set, or a nucleotide specifically bonded to a polynucleotide sequence coding one or more proteins selected from a group including apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 3A (APOBEC3A), fragment of IgG, low affinity IIIb (FCGR3B), serpin family B member 5 (SERPINB5), neuromedin-U (NMU), or protein-arginine deiminase type-2 (PADI2), or an antibody, an antigen-binding fragment, or a polypeptide, which are specifically bonded to one or more proteins or each fragment thereof selected from a group including APOBEC3A, FCGR3B, SERPINB5, NMU, and PADI2 or each fragment thereof.
机译:本发明涉及用于诊断转移性胃癌的组合物,以及使用该方法预测在胃癌初始阶段的淋巴结转移的方法。根据本发明,该组合物包含探针,引物组或特异性结合至编码选自载脂蛋白B mRNA编辑酶催化多肽样3A(APOBEC3A),片段的一种或多种蛋白的多核苷酸序列的核苷酸。 IgG,低亲和力IIIb(FCGR3B),丝氨酸蛋白酶抑制剂B家族5成员(SERPINB5),神经调节素U(NMU)或2型精氨酸脱亚氨酶(PADI2)或抗体,抗原结合片段或多肽,其特异性结合至选自APOBEC3A,FCGR3B,SERPINB5,NMU和PADI2的一个或多个蛋白质或其每个片段或其每个片段。

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