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Nitric oxide inhalation therapy for infants with bronchiolitis

机译:一氧化氮吸入治疗婴儿毛细支气管炎

摘要

In some embodiments, the invention provides a method of treating bronchiolitis in a child in need of treatment comprising administering to the infant a gaseous mixture comprising nitric oxide repeatedly at a concentration of about 144 to about 176 ppm for a first period of time , And administering a gas mixture that does not contain nitric oxide for a second time, wherein administration comprises: a) an oxygen saturation of 92% or greater in the room air compared to an infant who has not undergone repeated administration of nitric oxide Reduce the length of hospitalization required to achieve; b) reduce the length of hospitalization required to achieve a clinical score of 5 or less, as compared to an infant who has not undergone repeated administration of nitric oxide; c) reduce the length of hospitalization required to discharge compared to infants who have not undergone repeated administration of nitric oxide; d) any combination of these is repeated for a sufficient time.
机译:在一些实施方案中,本发明提供了一种在需要治疗的儿童中治疗细支气管炎的方法,该方法包括在第一时间段内以大约144ppm至大约176ppm的浓度向婴儿施用含一氧化氮的气态混合物,并且第二次不含一氧化氮的混合气体,其中给药包括:a)与未重复给药一氧化氮的婴儿相比,室内空气中的氧饱和度为92%或更高需要达到; b)与未重复服用一氧化氮的婴儿相比,减少了达到5分或更低的临床评分所需的住院时间; c)与没有反复服用一氧化氮的婴儿相比,缩短了出院所需的住院时间; d)将这些方法的任何组合重复足够的时间。

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