首页> 外国专利> METHOD FOR PRODUCING MESENCHYMAL STEM CELLS, THERAPEUTIC EFFECT MARKER OF MESENCHYMAL STEM CELLS, METHOD FOR DETERMINING THERAPEUTIC EFFECTS OF MESENCHYMAL STEM CELLS, AND CELLULAR PREPARATION CONTAINING MESENCHYMAL STEM CELLS

METHOD FOR PRODUCING MESENCHYMAL STEM CELLS, THERAPEUTIC EFFECT MARKER OF MESENCHYMAL STEM CELLS, METHOD FOR DETERMINING THERAPEUTIC EFFECTS OF MESENCHYMAL STEM CELLS, AND CELLULAR PREPARATION CONTAINING MESENCHYMAL STEM CELLS

机译：制备间充质干细胞的方法，间充质干细胞的治疗作用标记物，测定间充质干细胞的治疗作用的方法以及包含间充质干细胞的细胞制备

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摘要

[Problem] To provide a cellular preparation containing highly therapeutically effective mesenchymal stem cells (MSCs). [Solution] The present invention provides a method for producing activated MSCs, the method comprising a step for using a cell culture carrier having a three-dimensional structure consisting of fibers to culture MSCs in a medium containing an activating agent derived from a mammalian fetal appendage. Also, provided are: a therapeutic effect marker of MSCs, wherein the marker is selected from the group consisting of p16^ink4a, p14^ARF, CDK4, CDK6, RB, and CD47; a method for determining therapeutic effects using said marker; a method for determining the adaptability of MSCs with respect to a treatment for enhancing therapeutic effects; a cell preparation containing MSCs; and a method for producing the cell preparation.

机译：[问题]提供一种包含高度治疗有效的间充质干细胞（MSC）的细胞制剂。 [解决方案]本发明提供了一种制备活化的MSC的方法，该方法包括以下步骤：使用具有由纤维组成的三维结构的细胞培养载体，在含有源自哺乳动物胎儿附件的活化剂的培养基中培养MSC。。还提供：MSC的治疗效果标记，其中所述标记选自p16 ^{ink4a ，p14 ^{ARF ，CDK4，CDK6，RB和CD47 ;使用所述标记物确定治疗效果的方法;用于确定MSC对增强治疗效果的治疗的适应性的方法;含有MSC的细胞制剂;以及制备细胞制剂的方法。}}

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公开/公告号WO2018199194A1

专利类型
公开/公告日2018-11-01

原文格式PDF
申请/专利权人 SAPPORO MEDICAL UNIVERSITY;
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申请/专利号WO2018JP16883
发明设计人 CHIKENJI TAKAKO;FUJIMIYA MINEKO;SAITO YUKI;NAKANO MASAKO;OTANI MIHO;MIZUE YUKA;MATSUMURA TAKASHI;KAMIYA KOZUE;
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申请日2018-04-25
分类号C12N5/0775;A61K35/28;C12Q1/6851;G01N33/53;C12N15/09;
国家 WO
入库时间 2022-08-21 12:42:06

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