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MESENCHYMAL STEM CELL LINE USEFUL FOR DEVELOPING FIBROSIS TREATMENT AGENT
MESENCHYMAL STEM CELL LINE USEFUL FOR DEVELOPING FIBROSIS TREATMENT AGENT
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机译：骨髓间充质干细胞系可用于发展纤维化治疗剂
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摘要
The present invention relates to a mesenchymal stem cell line useful for developing a fibrosis treatment agent and, particularly, to hepatic stellate cell-derived mesenchymal stem cell line ONGHEPA1(KCTC 13086BP) which is characterized by inducing fibrosis by way of TGF-β or PDGF treatment, and to a method for screening a fibrosis treatment agent by using the mesenchymal stem cell line. The mesenchymal stem cell line according to the presentinvention can be very useful not only as a fibrosis model of a cell or tissue, but also as a cell for developing a new fibrosis treatment agent. Further, the screening method according to the present invention can accurately and efficiently screen a fibrosis treatment agent from a variety of candidate substances.
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