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TRIPLE REPORTER GENE EXPRESSION ANIMAL MODEL

机译:三重报告基因表达动物模型

摘要

The present invention relates to a recombinant vector for producing a triple reporter gene expression animal model, a triple reporter gene expression animal model, and a method for producing the same. When the triple reporter gene expression animal model according to the present invention is used, all triple imaging reporter genes are expressed, such that bioimaging, fluorescent imaging, luminous imaging, and nuclear medicine imaging are possible. Therefore, accurate information can be provided through multi-imaging. Accordingly, the triple reporter gene expression animal model can be used not only to diagnose various tumors and diseases early but also to trace the movement of various cells such as immunocytes, beta cells, and stem cells and the like used in cytotherapy. In addition, since usage in multi-imaging is possible even when using only cells of the triple reporter gene expression animal model of the present invention, an introduction step of additional reporter genes is excluded, and genetic deformation of unnecessary cells is limited. Accordingly, the triple reporter gene expression animal model is economical.
机译:本发明涉及用于产生三重报告基因表达动物模型的重组载体,三重报告基因表达动物模型及其产生方法。当使用根据本发明的三重报告基因表达动物模型时,所有三重成像报告基因均被表达,使得生物成像,荧光成像,发光成像和核医学成像成为可能。因此,可以通过多重成像来提供准确的信息。因此,三重报告基因表达动物模型不仅可以用于早期诊断各种肿瘤和疾病,而且可以追踪用于细胞疗法的各种细胞如免疫细胞,β细胞和干细胞等的运动。另外,由于即使仅使用本发明的三重报告基因表达动物模型的细胞也可以在多成像中使用,因此排除了另外的报告基因的导入步骤,并且限制了不必要细胞的遗传变形。因此,三重报道基因表达动物模型是经济的。

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