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GENETICALLY-MODIFIED TRYPANOSOMA CRUZI HAVING CALCIUM INDICATOR, AND APPLICATION OF SAID TRYPANOSOMA CRUZI FOR SCREENING OF ANTI-TRYPANOSOME AGENT
GENETICALLY-MODIFIED TRYPANOSOMA CRUZI HAVING CALCIUM INDICATOR, AND APPLICATION OF SAID TRYPANOSOMA CRUZI FOR SCREENING OF ANTI-TRYPANOSOME AGENT
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机译:具有钙指示剂的基因修饰的锥果克鲁维酵母及其在抗锥果糖原体筛选中的应用
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摘要
The present invention provides a genetically-modified Trypanosoma cruzi having a calcium indicator, and an application of said Trypanosoma cruzi for screening of an anti-trypanosome agent. More specifically, the present invention provides: a genetically-modified Trypanosoma cruzi having, in the body thereof, an intracellular calcium indicator that includes a fused protein of a mammal-derived calmodulin, a myosin light chain kinase-derived peptide (M13 peptide), and a marker protein; and a screening method of an anti-trypanosome agent in which said Trypanosoma cruzi is used.
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