首页> 外国专利> GENETICALLY-MODIFIED TRYPANOSOMA CRUZI HAVING CALCIUM INDICATOR, AND APPLICATION OF SAID TRYPANOSOMA CRUZI FOR SCREENING OF ANTI-TRYPANOSOME AGENT

GENETICALLY-MODIFIED TRYPANOSOMA CRUZI HAVING CALCIUM INDICATOR, AND APPLICATION OF SAID TRYPANOSOMA CRUZI FOR SCREENING OF ANTI-TRYPANOSOME AGENT

机译:具有钙指示剂的基因修饰的锥果克鲁维酵母及其在抗锥果糖原体筛选中的应用

摘要

The present invention provides a genetically-modified Trypanosoma cruzi having a calcium indicator, and an application of said Trypanosoma cruzi for screening of an anti-trypanosome agent. More specifically, the present invention provides: a genetically-modified Trypanosoma cruzi having, in the body thereof, an intracellular calcium indicator that includes a fused protein of a mammal-derived calmodulin, a myosin light chain kinase-derived peptide (M13 peptide), and a marker protein; and a screening method of an anti-trypanosome agent in which said Trypanosoma cruzi is used.
机译:本发明提供了具有钙指示剂的遗传修饰的克氏锥虫,以及所述的克氏锥虫在筛选抗锥虫剂中的应用。更具体地,本发明提供:遗传修饰的克氏锥虫,在其体内具有细胞内钙指示剂,其包括哺乳动物来源的钙调蛋白的融合蛋白,肌球蛋白轻链激酶来源的肽(M13肽),和标记蛋白;以及使用上述克氏锥虫的抗锥虫剂的筛选方法。

著录项

  • 公开/公告号WO2018034298A1

    专利类型

  • 公开/公告日2018-02-22

    原文格式PDF

  • 申请/专利权人 RIKEN;

    申请/专利号WO2017JP29418

  • 申请日2017-08-16

  • 分类号C12N1/11;C12N15/09;C12Q1/02;

  • 国家 WO

  • 入库时间 2022-08-21 12:45:35

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