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VARIABLE DOMAINS OF CAMELID HEAVY-CHAIN ANTIBODIES DIRECTED AGAINST GLIAL FIBRILLARY ACIDIC PROTEINS

机译:胶质原纤维酸性蛋白定向的可变重链抗体域

摘要

The present invention relates to the use of variable domains of camelid heavy-chain antibodies (VHH domains) di-rectedagainst an intracellular target and having an isoelectric point of at least8.5, for targeting said intracellular target or for thepreparation of a peptide vector. Particularly, it concerns VHH domainsdirected against a glial fibrillary acidic protein and usesthereof for preparing therapeutic or diagnostic agents.
机译:本发明涉及骆驼重-直链抗体(VHH结构域)对细胞内靶标且等电点至少为8.5,用于靶向所述细胞内靶标或用于肽载体的制备。特别是,它涉及VHH域针对神经胶质纤维酸性蛋白及其用途其用于制备治疗剂或诊断剂。

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