首页> 外国专利> Dynamics of the reason for sFlt-1 or endoglin / PLGF as an indicator of impending preeclampsia and / or HELLP syndrome

Dynamics of the reason for sFlt-1 or endoglin / PLGF as an indicator of impending preeclampsia and / or HELLP syndrome

机译:sFlt-1或内皮糖蛋白/ PLGF作为即将发生的先兆子痫和/或HELLP综合征的指标的动态

摘要

A method for diagnosing if a pregnant subject is at risk of developing preeclampsia within a short period of time comprising: a) determining the amounts of tyrosine biomarkers kinase soluble fms-1 (sFlt-1) or endoglin and factor placental growth (PlGF) in a first and a second sample of said subject, wherein said first sample has been obtained before said second sample; b) calculating a first ratio from said amounts of sFlt-1 or PlGF endoglin and determined in the first sample and a second ratio from said amounts of sFlt-1 or PlGF endoglin and determined in the second sample; c) comparing the value of said first and said second ratio, whereby it is diagnosed that a subject is at risk of developing preeclampsia within a short period of time if the value of the second reason is increased compared to the value the first reason a factor of at least 3 ± 20%.
机译:一种用于诊断怀孕受试者是否在短时间内有先兆子痫风险的方法,包括:a)确定酪氨酸生物标志物激酶可溶性fms-1(sFlt-1)或内皮糖蛋白和因子胎盘生长(PlGF)的量。所述受试者的第一和第二样品,其中所述第一样品已经在所述第二样品之前获得; b)根据所述sFlt-1或PlGF内皮糖蛋白的所述量在第一样品中确定的第一比例和根据所述sFlt-1或PlGF内皮糖蛋白的所述量在第二样品中确定的第二比例; c)比较所述第一比率和所述第二比率的值,由此如果第二原因的值与第一原因的值相比增加,则被诊断出受试者在短时间内有先兆子痫的风险。至少3±20%。

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