A method for identifying the modulators of the p11 protein (also known as S100-A10) useful for treating or alleviating disorders related to the p11 / 5-HT receptor, the method comprising: (A) identifying modulators of p11, comprising the steps of providing a first sample and a second sample, wherein the sample comprises peripheral blood mononuclear cells containing equivalent amounts of p11 gene product (eg, protein or mRNA); contact the first sample with the candidate p11 modulator; and determine if the amounts of p11 gene product in the first sample have changed, where an increased amount of gene product indicates that candidate modulators may be useful for treating or alleviating disorders associated with an abnormally low level of p11 while a decreased amount indicates that candidate modulators may be useful for treating or alleviating disorders associated with an abnormally high level of p11, or (B) identifying p11 modulators, which comprises contacting a candidate p11 modulator with a sample comprising blood mononuclear cells peripherals comprising an indicator gene functionally linked to a p11 promoter and using the level of gene expression of the indicator as a proxy for the expression of p11, wherein an increased amount of the gene product of the indicator indicates that candidate modulators may be useful for treating or relieve disorders associated with an abnormally low level of p11 while f a diminished amount indicates that candidate modulators may be useful for treating or alleviating disorders associated with the abnormally high level of p11.
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