首页> 外国专利> METHOD OF IDENTIFICATION OF A SOLUBLE SET OF BIOMARKERS FOR DIAGNOSIS, PROGNOSIS AND MONITORING OF GLIOBLASTOMA, AND METHOD FOR DIAGNOSIS, PROGNOSIS OR MONITORING OF GLIOBLASTOMA BASED ON THE USE OF SAID SET

METHOD OF IDENTIFICATION OF A SOLUBLE SET OF BIOMARKERS FOR DIAGNOSIS, PROGNOSIS AND MONITORING OF GLIOBLASTOMA, AND METHOD FOR DIAGNOSIS, PROGNOSIS OR MONITORING OF GLIOBLASTOMA BASED ON THE USE OF SAID SET

机译：基于胶质母细胞瘤的诊断，预后和监测的生物标志物可溶组的鉴定方法，胶质母细胞瘤的诊断，预后或监测的方法

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摘要

The invention relates to a method of identification of a set of biomarkers to be used in prognosis and diagnosis of brain tumours. According to the invention, the method comprises the simultaneous determination of serum and plasma concentration in samples taken from patients suffering from glioblastoma versus the control of a complex of cytokines and angiogenic factors IL-1β , IL-6, TNF alpha and VEGF, the values of which are 1.5...10 times higher than the average normal values, and the simultaneous use thereof as a set of biomarkers for monitoring brain tumours.

机译：本发明涉及一种鉴定用于脑肿瘤的预后和诊断的生物标志物的方法。根据本发明，该方法包括同时测定得自胶质母细胞瘤患者的样品中的血清和血浆浓度，而不是对照细胞因子和血管生成因子IL-1β，IL-6，TNFα和VEGF的复合物，其中比平均正常值高1.5 ... 10倍，并且可以同时将其用作监测脑肿瘤的一组生物标记。

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公开/公告号RO130590B1

专利类型
公开/公告日2018-08-30

原文格式PDF
申请/专利权人 INSTITUTUL NAŢIONAL DE CERCETARE-DEZVOLTARE ÎN DOMENIUL PATOLOGIEI ŞI ŞTIINŢELOR BIOMEDICALE VICTOR BABEŞ;
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申请/专利号RO20130000409
发明设计人 TĂNASE CRISTIANA;ALBULESCU RADU NICOLAE AUREL;CODRICI ELENA;MIHAI SIMONA;ALBULESCU LUCIAN;POPESCU IONELA DANIELA;CONSTANTINESCU ŞTEFAN;
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申请日2013-05-28
分类号G01N33/574;
国家 RO
入库时间 2022-08-21 12:50:12

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