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Transcriptomic biomarkers, method of determination and application of transcriptomic biomarkers for the stratification of the individual risk of development of the post-heart failure cardiac insufficiency

机译:转录组生物标志物,转录组生物标志物的测定方法和用于将心力衰竭后心脏功能不全的个体发展风险分层的方法

摘要

The invention relates to biomarkers for individual risk assessment of the development of post-infarction heart failure, the method of determining the markers in samples of biological material collected from a patient. Further, the invention relates to a use of the biomarkers in the diagnosis (expression level of the gene) that correlate with the developing post-infarction heart failure, and enable prevention of heart disease based on a genetic marker and a method for predicting the risk of developing a heart failure for post-infarction patients. Also a method for optimizing the treatment of cardiac patients with the use of the means of the invention is disclosed.
机译:本发明涉及用于对梗塞后心力衰竭的发展进行个体风险评估的生物标志物,该方法是确定从患者收集的生物材料样品中的标志物的方法。此外,本发明涉及生物标志物在诊断中的用途(基因的表达水平),其与发展中的梗塞后心力衰竭相关,并且能够基于遗传标志物预防心脏病,以及预测风险的方法为梗塞后患者发展心力衰竭。还公开了一种使用本发明的手段优化心脏病患者治疗的方法。

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