首页> 外国专利> EVALUATION OF NEUROPROTECTIVE EFFECT OF ETHANOLIC EXTRACT OF BOSWELLIA SERRATA OLEO GUM RESIN ON HALOPERIDOL INDUCED PARKINSON`S DISEASE IN SWISS ALBINO MICE

EVALUATION OF NEUROPROTECTIVE EFFECT OF ETHANOLIC EXTRACT OF BOSWELLIA SERRATA OLEO GUM RESIN ON HALOPERIDOL INDUCED PARKINSON`S DISEASE IN SWISS ALBINO MICE

机译:乳香提取物对卤代哌多尔致人帕金森病的神经保护作用评价。

摘要

Parkinson?s is a clinical syndrome characterized by rigidity, tremors, bradykinasia and improper gait. The present study evaluated the neuroprotective effect of ethanolic extract of Boswellia serrata oleo gum resin on haloperidol induced Parkinson?s disease in Swiss albino mice. Animals were divided into 6 groups 5 animals each for the study. Ethanolic extract of Boswellia serrata oleo gum resin 500mg/kg when give orally has shown better result when compared to that of carbidopa treated group. Catalepsy activity, Actophotometer method, wire hanging test, grip strength test, vertical pole test, FST were determined for the screening Neuroprotective effect of this plant extract. Boswellia serrata oleo gum resin 500mg/kg has reduced the free radical levels also by showing positive effect in SOD, MDA, GSH.
机译:帕金森氏病是一种临床综合征,其特征是僵硬,震颤,运动迟缓和步态不当。本研究评估了乳香乳香树胶树脂提取物对氟哌啶醇诱发的瑞士白化病小鼠的神经保护作用。将动物分为6组,每组5只动物用于研究。与卡比多巴治疗组相比,口服给予乳香乳香树胶树脂500mg / kg的乙醇提取物显示出更好的效果。确定了僵尸活性,光度计法,钢丝悬挂试验,握力试验,垂直杆试验,FST,以筛选该植物提取物的神经保护作用。乳香锯缘青蟹油树脂500mg / kg通过在SOD,MDA,GSH中显示出积极作用,也降低了自由基水平。

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