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ANTI AGGRUS MONOCLONAL ANTIBODY DOMAIN IN AGGRUS WHICH IS REQUIRED FOR BINDING TO CLEC 2 AND METHOD FOR SCREENING FOR AGGRUS CLEC 2 BINDING INHIBITOR
ANTI AGGRUS MONOCLONAL ANTIBODY DOMAIN IN AGGRUS WHICH IS REQUIRED FOR BINDING TO CLEC 2 AND METHOD FOR SCREENING FOR AGGRUS CLEC 2 BINDING INHIBITOR
A novel domain in Aggrus which is involved in the binding to CLEC 2 was searched and a monoclonal antibody capable of recognizing the domain was obtained. It is clearly found that a newly discovered PLAG4 domain is important for the binding to CLEC 2 and a monoclonal antibody capable of recognizing the domain is produced. It becomes possible to provide a novel Aggrus CLEC 2 binding inhibitor a novel platelet aggregation inhibitor and a novel cancer metastasis inhibitor using the antibody.
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