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DESIGN, SYNTHESIS CHARACTERIZATION AND BIOLOGICAL EVALUATION OF SOME NOVEL HETERO CYCLIC DERIVATIVES AS ANTI-TUBERCULAR AGENTS
DESIGN, SYNTHESIS CHARACTERIZATION AND BIOLOGICAL EVALUATION OF SOME NOVEL HETERO CYCLIC DERIVATIVES AS ANTI-TUBERCULAR AGENTS
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机译：一些新型抗杂环化合物的设计，合成表征及生物学评价
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Abstract In the present work, some Novei Heterocyclic derivatives were synthesized, characterized and evaluated for anti-tubercular activity. The compounds were synthesized by stirring and reflux condensation method. The chemical structures of synthesized compound were confirmed by IR, NMR and MASS spectral analysis. Crystals suitable for X-ray crystallographic studies for one derivative was performed and confirmed. The synthesized compounds were initially investigated for in-viiro anti-tubercular activity (MABA- Micro-liter Alamar Blue Assay). The concentrations at which the compounds are sensitive were determined and found that they are sensitive at lower concentration. Synthesized compounds which exhibit promising In-vitro anti-tubercular activity were subjected to acute toxicity studies in order to find out the toxicity induced mortality and other behavioral changes. Further with the acute toxicity results, and in-vitro anti-tubercular activity rankings top 3 compounds selected and subjected for in-vivo anti-tubercular activity study.
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