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METHODS AND COMPOSITIONS FOR TARGETED TWO-DIMENSIONAL WESTERN BLOT ANALYSIS FOR EARLY CANCER DETECTION AND CANCER DIAGNOSIS UP TO TEN YEARS IN ADVANCE OF CLINICAL SYMPTOMS OF MALIGNANT DISEASE
METHODS AND COMPOSITIONS FOR TARGETED TWO-DIMENSIONAL WESTERN BLOT ANALYSIS FOR EARLY CANCER DETECTION AND CANCER DIAGNOSIS UP TO TEN YEARS IN ADVANCE OF CLINICAL SYMPTOMS OF MALIGNANT DISEASE
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机译：针对二维疾病早期诊断和诊断的二维二维蛋白质印迹分析的方法和组成
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摘要
The present invention includes methods for detecting benign to malignant transformation of a cancer in a subject, comprising the steps of: collecting a sample from the subject prior to electrophoretic protein separation; activating electrophoretically separated ENOX2 transcript variants with an ENOX2 electron donor; and detecting the presence of the one or more activated ENOX2 transcript variants using a pan-ENOX2 detectable binding reagent, wherein the presence of one or more activated ENOX2 transcript variants in the sample is indicative of the malignant transformation of the cancer, whereby a 10 to 100 fold increase in detection sensitivity is obtained for the one or more activated ENOX2 transcript variants when compared to an equivalent non-activated ENOX2 transcript variant.
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