首页> 外国专利> CRINUM ASIATICUM (FAMILY AMARYLLIDACEAE) -THE POTENTIAL PLANT BASED SOURCE FOR A POTENT ANTIMALARIAL AGENT AGAINST PLASMODIUM FALCIPARUM

CRINUM ASIATICUM (FAMILY AMARYLLIDACEAE) -THE POTENTIAL PLANT BASED SOURCE FOR A POTENT ANTIMALARIAL AGENT AGAINST PLASMODIUM FALCIPARUM

机译：CRINUM ASIATICUM（Family AMARYLLIDACEAE）-恶性疟原虫潜在抗药性药剂的潜在植物来源

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摘要

The present invention is related to the collection of an indigenous ethnomedicinal plant species Crinum asiaticum from Assam, India, preparation of crude extract from its bulbs using chloroform as a solvent and evaluating its antiplasmodial activity against Plasmodium falciparum, the major causative agent of human malaria. The in-vitro antiplasmodial activity screening was done against two references of P.falciparum strains, RKL-2(chloroquine resistant strain) and 3D-7(chloroquine sensitive strain), using schizont inhibition assays. The crude chloroform (moderately polar solvent) extract of the bulb of the plant species Crinum asiaticum was found to have a highly active antiplasmodial activity against both the strains of P.falciparum mentioned above. The herbal formulation of Crinum asiaticum and another plant Curanga amara juss had showed very promising antiplasmodial activity. The formulation did not show any toxicity on animal model and mammalian RBCs.

机译：本发明涉及从印度的阿萨姆邦（Assam），印度的土著民族药典植物物种Crimum asiaticum的收集，使用氯仿作为溶剂从其鳞茎制备粗提物，并评价其对人疟疾的主要病原体恶性疟原虫的抗疟原虫活性。使用裂殖体抑制试验，针对恶性疟原虫菌株的两个参考品，即RKL-2（氯喹抗性菌株）和3D-7（氯喹敏感菌株）进行了体外抗血浆活性筛选。已发现植物种Crimum asiaticum的鳞茎的粗氯仿（中等极性溶剂）提取物具有针对上述两种恶性疟原虫菌株的高活性抗疟原虫活性。 Crinum asiaticum和另一种植物Curanga amara juss的草药配方显示出非常有前途的抗疟原虫活性。该制剂对动物模型和哺乳动物RBC没有任何毒性。

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公开/公告号IN2014KO01202A

专利类型
公开/公告日2017-12-01

原文格式PDF
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申请/专利号IN1202/KOL/2014
发明设计人 PROF MOHAN CHANDRA KALITA;ANIL PRAKASH;KABITA GOGOI;NILAKSHI GOHAIN;D R BHATTACHARYYA;J MAHANTA;NILANJU PRAN SARMA;CHANDRAJIT DOHUTIA;P K MOHAPATRA;HRIDIP KUMAR SARMA;
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申请日2015-02-19
分类号A61K36/53;
国家 IN
入库时间 2022-08-21 12:52:18

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