首页> 外国专利> EFFECTIVE SYNTHESIS OF CHELATING AGENTS FOR NUCLEAR IMAGE AND RADIOTHERAPY: COMPOSITIONS AND APPLICATIONS

EFFECTIVE SYNTHESIS OF CHELATING AGENTS FOR NUCLEAR IMAGE AND RADIOTHERAPY: COMPOSITIONS AND APPLICATIONS

机译:核图像和放射疗法螯合剂的有效合成:组成和应用

摘要

Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.
机译:公开了靶向螯合剂的配体缀合物的新颖的合成方法,包含此类缀合物的组合物以及此类缀合物的治疗和诊断应用。该组合物包括任选螯合至一种或多种金属离子的靶向螯合剂的配体缀合物。还提出了以高纯度合成这些组合物的方法。还公开了使用这些新颖的组合物对受试者中的疾病进行成像,治疗和诊断的方法,例如对受试者内的肿瘤进行成像的方法以及诊断心肌缺血的方法。

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