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EFFECTIVE SYNTHESIS OF CHELATING AGENTS FOR NUCLEAR IMAGE AND RADIOTHERAPY: COMPOSITIONS AND APPLICATIONS
EFFECTIVE SYNTHESIS OF CHELATING AGENTS FOR NUCLEAR IMAGE AND RADIOTHERAPY: COMPOSITIONS AND APPLICATIONS
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机译:核图像和放射疗法螯合剂的有效合成:组成和应用
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摘要
Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.
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