Current descriptions provide components and methods related to or derived from proteins and antigens to initiate GF21 mediated signaling. In morphology, antigen linked proteins are specifically linked to a (I) - Klotho; (I) fgfr1c, fgfr2c, fgfr3c or FGFR4; or (III) a complex of Klotho and fgfr1c, fgfr2c, fgfr3c and FGFR4. In some cases, antigen linked proteins can trigger fg21 signals. In some cases, antigen linked proteins are completely human, human or cosmetic antibodies, linked fragments and derivatives of such antibodies,(I) fgfr1c, fgfr2c, fgfr3c or FGFR4; or (III) a complex composed of Klotho and fgfr1c, fgfr2c, fgfr3c and FGFR4, and other forms of FGFR4 provide nucleic acids to encode such antigen linked proteins, their fragments and derivatives, and peptides; Including the processing methods and polypeptides of the polynucleotide, antigen linked protein, its parts and derivatives, and the use methods of the antigen linked protein, its fragments and derivatives and polypeptides,Includes methods for treating or diagnosing patients with type 2 diabetes, obesity, Nash, metabolic syndrome, and related diseases or conditions.
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