首页> 外国专利> monoclonal antibody, light chain and heavy chain variable regions, isolated cdr, polynucleotide, therapeutic composition, methods for treating disease and disorder, for producing an antibody, for treating or alleviating the effects of disease and disorder, for reducing plaque burden in an individual's brain, to reduce the amount of plaque in an individual's brain, to decrease the total amount of soluble spruce in an individual's brain, to retain or increase an individual's cognitive memory capacity, to diagnose from or to diagnose a predisposition to an amyloid-associated disease or condition in a patient, to determine the extent of amyloidogenic plaque burden in an individual's tissue, to monitor minimal residual disease in an individual, and to predict an individual's responsiveness, cell line , test kit, epitope fir

monoclonal antibody, light chain and heavy chain variable regions, isolated cdr, polynucleotide, therapeutic composition, methods for treating disease and disorder, for producing an antibody, for treating or alleviating the effects of disease and disorder, for reducing plaque burden in an individual's brain, to reduce the amount of plaque in an individual's brain, to decrease the total amount of soluble spruce in an individual's brain, to retain or increase an individual's cognitive memory capacity, to diagnose from or to diagnose a predisposition to an amyloid-associated disease or condition in a patient, to determine the extent of amyloidogenic plaque burden in an individual's tissue, to monitor minimal residual disease in an individual, and to predict an individual's responsiveness, cell line , test kit, epitope fir

机译:单克隆抗体,轻链和重链可变区,分离的cdr,多核苷酸,治疗组合物,用于治疗疾病和病症的方法,用于生产抗体的抗体,用于治疗或减轻疾病和病症的影响,用于减轻个体大脑斑块负担的方法,以减少个体大脑中的斑块数量,减少个体大脑中的可溶性云杉总量,保持或增加个体的认知记忆能力,诊断或诊断淀粉样蛋白相关疾病的易感性,或患者的身体状况,确定个体组织中淀粉样蛋白斑块负担的程度,监测个体中的最小残留疾病并预测个体的反应能力,细胞系,检测试剂盒,抗原决定簇

摘要

The present application is related to methods and compositions for the therapeutic and diagnostic use in the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis, a group of disorders and abnormalities associated with amyloid protein such as Alzheimer's disease. The present application provides novel methods and compositions comprising highly specific and highly effective antibodies having the ability to specifically recognize and bind to specific epitopes from a range of ²-amyloid proteins. The antibodies enabled by the teaching of the present application are particularly useful for the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis, a group of diseases and disorders associated with amyloid plaque formation including secondary amyloidosis and age-related amyloidosis including, but not limited to, neurological disorders such as Alzheimer's Disease (AD).
机译:本申请涉及用于治疗和诊断用途的方法和组合物,所述方法和组合物用于治疗由淀粉样蛋白或淀粉样蛋白样蛋白(包括淀粉样变性病)引起的或与之相关的疾病和病症,与淀粉样蛋白如阿尔茨海默氏病。本申请提供了新颖的方法和组合物,其包含高度特异性和高效的抗体,所述抗体具有特异性识别并结合来自一系列β-淀粉样蛋白的特定表位的能力。通过本申请的教导使能的抗体对于治疗由淀粉样蛋白或淀粉样蛋白样蛋白引起或与之相关的疾病和病症特别有用,所述蛋白质和淀粉样蛋白包括淀粉样变性病,与淀粉样斑块形成有关的一组疾病和紊乱包括继发性淀粉样变性病与年龄有关的淀粉样变性病,包括但不限于神经系统疾病,例如阿尔茨海默氏病(AD)。

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