首页> 外国专利> antibody, methods for neutralizing infectious ebov, preventing, treating or ameliorating at least one ebov infection symptom or decreasing the frequency or severity of at least one ebov infection symptom and for increasing the survival or likelihood of survival of an individual suffering from ebov infection or an individual exposed to ebov or at risk of ebov exposure or acquisition, pharmaceutical composition, isolated polynucleotide molecule, vector, and cell.

antibody, methods for neutralizing infectious ebov, preventing, treating or ameliorating at least one ebov infection symptom or decreasing the frequency or severity of at least one ebov infection symptom and for increasing the survival or likelihood of survival of an individual suffering from ebov infection or an individual exposed to ebov or at risk of ebov exposure or acquisition, pharmaceutical composition, isolated polynucleotide molecule, vector, and cell.

机译:抗体,中和感染性ebov,预防,治疗或改善至少一种ebov感染症状或降低至少一种ebov感染症状的频率或严重程度,以及增加遭受ebov感染或感染的个体的存活率或存活可能性的方法暴露于ebov或有ebov暴露或获取风险的个体,药物组合物,分离的多核苷酸分子,载体和细胞。

摘要

The present invention provides monoclonal antibodies, or antigen binding fragments thereof, that bind to ebola virus glycoproteins, pharmaceutical compositions comprising the antibodies and methods of use. The antibodies of the invention are useful for inhibiting or neutralizing Ebola virus activity, thus providing a means of treating or preventing Ebola virus infection in humans. In some embodiments, the invention provides the use of one or more antibodies that bind to the ebola virus to prevent viral binding and / or entry into host cells. The antibodies of the invention may be used prophylactically or therapeutically and may be used alone or in combination with one or more other antiviral agents or vaccines.
机译:本发明提供了与埃博拉病毒糖蛋白结合的单克隆抗体或其抗原结合片段,包含该抗体的药物组合物和使用方法。本发明的抗体可用于抑制或中和埃博拉病毒活性,从而提供治疗或预防人类埃博拉病毒感染的手段。在一些实施方案中,本发明提供了一种或多种与埃博拉病毒结合的抗体在预防病毒结合和/或进入宿主细胞中的用途。本发明的抗体可以预防性地或治疗性地使用,并且可以单独使用或与一种或多种其他抗病毒剂或疫苗组合使用。

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