首页> 外国专利> isolated fusion protein, and methods for treating or alleviating a symptom of a disease or disorder, for treating or alleviating an inflammation or symptom of an inflammatory disease or disorder, and for reducing the risk of infection in an individual.

isolated fusion protein, and methods for treating or alleviating a symptom of a disease or disorder, for treating or alleviating an inflammation or symptom of an inflammatory disease or disorder, and for reducing the risk of infection in an individual.

机译:分离的融合蛋白,以及用于治疗或减轻疾病或病症的症状,用于治疗或减轻炎症性疾病或病症的炎症或症状并降低个体感染风险的方法。

摘要

This invention relates to molecules, particularly polypeptides, more particularly fusion proteins which include a snake polypeptide or amino acid sequence that is derived from a snake and a second polypeptide comprising at least one of the following: an fc polypeptide or a sequence of amino acids which is derived from an fc polypeptide; a cytokine targeted polypeptide or sequence derived from a cytokine targeted polypeptide; a wap domain containing polypeptide or a sequence derived from a wap domain containing polypeptide; and an albumin polypeptide or amino acid sequence that is derived from a serum albumin polypeptide. This invention also relates to methods of using such molecules in a variety of therapeutic and diagnostic indications, as well as methods of producing such molecules.
机译:本发明涉及分子,特别是多肽,更特别地涉及融合蛋白,其包括蛇毒多肽或源自蛇的氨基酸序列和包含以下至少一种的第二多肽:fc多肽或氨基酸序列,其衍生自fc多肽;细胞因子靶向多肽或衍生自细胞因子靶向多肽的序列;包含wap结构域的多肽或源自包含wap结构域的多肽的序列;以及源自血清白蛋白多肽的白蛋白多肽或氨基酸序列。本发明还涉及在各种治疗和诊断适应症中使用此类分子的方法,以及产生此类分子的方法。

著录项

  • 公开/公告号BR112017008525A2

    专利类型

  • 公开/公告日2018-01-30

    原文格式PDF

  • 申请/专利权人 INHIBRX LP;

    申请/专利号BR20171108525

  • 申请日2015-10-27

  • 分类号C07K16;A61P37;

  • 国家 BR

  • 入库时间 2022-08-21 12:53:51

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