首页> 外国专利> methods for treating or preventing respiratory infection, copd and copd exacerbation and for selecting a notch 3 and / or notch4 signaling inhibitor, usp of a notch 3 and / or notch 4 signaling inhibitor, notch 3 signaling inhibitor and / or notch 4, and, pharmaceutical composition.

methods for treating or preventing respiratory infection, copd and copd exacerbation and for selecting a notch 3 and / or notch4 signaling inhibitor, usp of a notch 3 and / or notch 4 signaling inhibitor, notch 3 signaling inhibitor and / or notch 4, and, pharmaceutical composition.

机译：治疗或预防呼吸道感染，copd和copd加重以及选择notch 3和/或notch4信号抑制剂，usp 3和/或notch 4信号抑制剂，usp 3信号抑制剂和/或notch 4的方法，以及，药物组合物。

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摘要

The present invention relates to methods for treating or preventing respiratory infections, in particular, respiratory infections in patients with an underlying respiratory disorder, such as chronic obstructive pulmonary disease (COPD). The present invention also relates to methods for treating or preventing copd or copd exacerbations. The invention particularly describes the role of notch 3 and / or notch 4 signaling in such methods and the use of notch 3 and / or notch 4 as therapeutic and selection targets.

机译：本发明涉及用于治疗或预防呼吸道感染的方法，特别是在患有潜在呼吸道疾病如慢性阻塞性肺病（COPD）的患者中的呼吸道感染。本发明还涉及治疗或预防copd或copd加重的方法。本发明特别描述了缺口3和/或缺口4信号传导在此类方法中的作用以及缺口3和/或缺口4作为治疗和选择靶标的用途。

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公开/公告号BR112017005828A2

专利类型
公开/公告日2018-01-30

原文格式PDF
申请/专利权人 GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED;
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申请/专利号BR20171105828
发明设计人 EDITH HESSEL;NIKOLAI NIKOLAEVICH BELYAEV;SOREN BEINKE;
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申请日2015-09-22
分类号A61K31;A61K31/5513;A61K39/395;
国家 BR
入库时间 2022-08-21 12:53:50

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