首页> 外国专利> Isolated antibody or antigen-binding fragment thereof, pharmaceutical composition, and methods for treating a cancer or tumor expressing egfrviii and for treating a cancer, reducing tumor growth and / or causing tumor regression in a patient ?

Isolated antibody or antigen-binding fragment thereof, pharmaceutical composition, and methods for treating a cancer or tumor expressing egfrviii and for treating a cancer, reducing tumor growth and / or causing tumor regression in a patient ?

机译:分离的抗体或其抗原结合片段,药物组合物和用于治疗表达egfrviii的癌症或肿瘤并用于治疗癌症,减少患者的肿瘤生长和/或引起肿瘤消退的方法?

摘要

The present disclosure provides antibodies that bind to the egfr class iii variant (egfrviii) and the methods of use thereof. according to certain embodiments, the antibodies of the description bind to human affinity with high affinity. The antibodies of the disclosure may be antibodies entirely from humans. Description includes anti-egfrviii antibodies conjugated to a cytotoxic agent, radionuclide, or other portion detrimental to cell growth or cell proliferation. The antibodies of the description are useful for treating various cancers.
机译:本公开内容提供了与egfr iii类变体(egfrviii)结合的抗体及其使用方法。根据某些实施方案,本说明书的抗体以高亲和力结合人亲和力。本公开的抗体可以是完全来自人的抗体。描述包括与细胞毒性剂,放射性核素或其他对细胞生长或细胞增殖有害的部分缀合的抗egfrviii抗体。本说明书的抗体可用于治疗各种癌症。

著录项

相似文献

  • 专利
  • 外文文献
  • 中文文献
获取专利

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号