首页> 外国专利> isolated antibody or antigen binding fragment thereof, drug-to-antibody conjugate, methods for eliminating cells expressing low levels of prlr and a class i cytokine receptor and for inhibiting or attenuating tumor growth, and, pharmaceutical composition

isolated antibody or antigen binding fragment thereof, drug-to-antibody conjugate, methods for eliminating cells expressing low levels of prlr and a class i cytokine receptor and for inhibiting or attenuating tumor growth, and, pharmaceutical composition

机译:分离的抗体或其抗原结合片段,药物-抗体缀合物,消除表达低水平的prlr和I类细胞因子受体的细胞并抑制或减弱肿瘤生长的方法以及药物组合物

摘要

The present disclosure provides prolactin receptor (prlr) binding antibodies, and methods for using them. according to certain embodiments, the antibodies of the description bind to human affinity with high affinity. in certain embodiments, the disclosure includes antibodies that bind to prlr and block prolactin-mediated cellular signaling. in other embodiments, the disclosure includes antibodies that bind to prlr but do not block prolactin-mediated cellular signaling. The antibodies of the disclosure may be fully human antibodies. The description includes anti-PRR antibodies conjugated to a cytotoxic agent, radionuclide, or other detrimental fraction for cell growth or proliferation. The antibodies of the description are useful for treating various cancers as well as other prlr-related disorders. The present disclosure also includes drug-to-antibody conjugates comprising an antibody or antigen binding fragment thereof that specifically binds to a class I cytokine receptor, wherein the antibody or antigen binding fragment thereof is conjugated to an agent. cytotoxic.
机译:本公开提供了催乳激素受体(prlr)结合抗体及其使用方法。根据某些实施方案,本说明书的抗体以高亲和力结合人亲和力。在某些实施方案中,本公开内容包括结合至pr1r并阻断催乳激素介导的细胞信号转导的抗体。在其他实施方案中,本公开包括结合至pr1r但不阻断催乳激素介导的细胞信号转导的抗体。本公开的抗体可以是完全人抗体。该描述包括缀合至细胞毒性剂,放射性核素或其他有害组分的抗PRR抗体,以促进细胞生长或增殖。本说明书的抗体可用于治疗各种癌症以及其他与prlr相关的疾病。本公开还包括药物-抗体缀合物,其包含特异性结合I类细胞因子受体的抗体或其抗原结合片段,其中所述抗体或其抗原结合片段缀合至试剂。细胞毒性。

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