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Biomarkers in Peripheral Blood Mononuclear Cells for Diagnosing or Detecting Lung Cancers

机译:外周血单个核细胞中用于诊断或检测肺癌的生物标志物

摘要

Methods and compositions are provided for diagnosing or detecting a condition, e.g., lung disease in a mammalian subject by use of a micro-RNA expression level or an expression level profile of multiple miRNA in the peripheral blood mononuclear cells (PBMC) of the subject which is characteristic of COPD or NSCLC. Detection of changes in expression in specific miRNA biomarkers from that of a reference sample or miRNA expression profile are correlated with non-small cell lung cancer (NSCLC) and/or COPD and permit differentiation among healthy subjects, subjects with COPD and subjects with adenocarcinoma or squamous cell carcinoma.
机译:提供了用于通过使用受试者的外周血单核细胞(PBMC)中的微小RNA表达水平或多种miRNA的表达水平概况在哺乳动物受试者中诊断或检测疾病例如肺部疾病的方法和组合物,是COPD或NSCLC的特征。从参考样品或miRNA表达谱检测特定miRNA生物标志物中表达变化的检测与非小细胞肺癌(NSCLC)和/或COPD相关,并可以区分健康受试者,COPD受试者和腺癌或鳞状细胞癌。

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