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Biomarkers in Peripheral Blood Mononuclear Cells for Diagnosing or Detecting Lung Cancers
Biomarkers in Peripheral Blood Mononuclear Cells for Diagnosing or Detecting Lung Cancers
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机译:外周血单个核细胞中用于诊断或检测肺癌的生物标志物
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摘要
Methods and compositions are provided for diagnosing or detecting a condition, e.g., lung disease in a mammalian subject by use of a micro-RNA expression level or an expression level profile of multiple miRNA in the peripheral blood mononuclear cells (PBMC) of the subject which is characteristic of COPD or NSCLC. Detection of changes in expression in specific miRNA biomarkers from that of a reference sample or miRNA expression profile are correlated with non-small cell lung cancer (NSCLC) and/or COPD and permit differentiation among healthy subjects, subjects with COPD and subjects with adenocarcinoma or squamous cell carcinoma.
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